Protein knots: A tangled problem
نویسندگان
چکیده
منابع مشابه
The tangled web of self-tying knots.
M athematician Leopold Kronecker stated “God created the integers, all else is the work of man,’’ alluding to the fact that the natural numbers most likely arose from physical counting, as in one’s fingers or goats in the pasture. Topology, however, is arguably a different creature altogether and may have had its own independent origins from the physical world in the ubiquitous knot—something t...
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Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into α4β4 rings. Here, we present the first X-ray structure of a gemcitabine-inhibited E. coli RNR and show that the previous...
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ژورنال
عنوان ژورنال: Nature
سال: 2003
ISSN: 0028-0836,1476-4687
DOI: 10.1038/421025a